Ozempic has become a household name, but it is not the only option for the medical treatment of obesity. There are several GLP-1 analogs and dual therapies available by prescription. The right choice depends on your clinical profile, your labs and your history.
In this article we explain the main alternatives and why the choice should always be made by a doctor.
GLP-1 analogs mimic an intestinal hormone that regulates appetite, satiety and blood glucose. Clinical trials have shown significant, sustained weight loss plus metabolic benefits.
These are prescription-only medicines: they cannot be bought without a prescription and their use must be supervised, because they require dose titration, safety labs and follow-up.
| Active ingredient | Brand name | Format | Profile |
|---|---|---|---|
| Semaglutide | Ozempic / Wegovy | Weekly injection | Well studied; effective for obesity |
| Liraglutide | Saxenda / Victoza | Daily injection | Classic option, daily titration |
| Tirzepatide | Mounjaro | Weekly injection | Dual GIP/GLP-1 therapy; larger weight loss |
| Oral semaglutide | Rybelsus | Daily tablet | Oral option for those avoiding injections |
Availability can vary by country and time (supply issues). A doctor will tell you which is appropriate based on your goals, comorbidities and contraindications.
There is no universal answer. The EASO 2025 European guidelines recommend individualizing the choice based on:
Before starting, a safety protocol (EASO) is followed: glucose, HbA1c, lipid profile, renal and liver function, and TSH. At TrueWeight we provide the lab request for your health center or private laboratory.
With a private medical prescription, the medication is dispensed at your pharmacy. The cost varies by product and format (approx. €100–€300/month). When used for obesity without diabetes it is typically not covered by public health, so payment is private.
These drugs have contraindications (history of medullary thyroid carcinoma, MEN2, etc.) and side effects (nausea, diarrhoea, vomiting) that are usually transient. That is why medical follow-up is essential: the dose is adjusted according to response and tolerance.
Complete the free medical assessment (10 minutes). A doctor will review your case and explain the options, with no obligation.
Start your free assessment →Medical disclaimer: this article is for information only and does not replace professional advice. The medicines mentioned are prescription-only. Do not use them without healthcare supervision.